THE EFFECT OF RED GUAVA LEAF (PSIDIUM GUAJAVA) INFUSION ON WOUND HEALING PROCESS IN MICE (MUS MUSCULUS ALBINUS): AN EXPERIMENTAL STUDY

Abstract

The wound healing process is a complex biological sequence, and Psidium guajava leaves are known for their antimicrobial and anti-inflammatory properties. This study aims to evaluate the effect of red guava leaf infusion on the wound healing process in mice. A true experimental study with a post-test only control group design was conducted on 24 male albino mice. Subjects were divided into four groups: negative control (saline), positive control (povidone-iodine), and two treatment groups with guava leaf infusion. Parameters included wound contraction rate and histopathological analysis (epithelialization, collagen, angiogenesis). The treatment groups showed significantly faster wound contraction compared to the negative control. Histopathology revealed better collagen density and re-epithelialization in the infusion-treated groups. Red guava leaf infusion accelerates wound healing and improves tissue regeneration quality.

Keywords: Psidium guajava; wound healing; mice; infusion; histopathology

Highlights:

1. Red guava leaf infusion significantly accelerates wound contraction rates in mice models compared to saline controls.
2. Histopathological analysis confirms enhanced collagen density and re-epithelialization in wounds treated with Psidium guajava.